Rathkes cleft-like cysts arise from Isl1 deletion in murine pituitary progenitors
نویسندگان
چکیده
This study used mouse models to investigate the role of LIM homeodomain transcription factor Isl1 in pituitary development. It reveals that has multiple, critical roles gland Pituitary-specific deletion caused hypopituitarism with increased stem cell apoptosis, reduced both differentiation thyrotropes and gonadotropes body size, even promoted development multiple Rathkes cleft-like cysts.
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ژورنال
عنوان ژورنال: Yearbook of pediatric endocrinology
سال: 2021
ISSN: ['1662-3991', '1662-4009']
DOI: https://doi.org/10.1530/ey.18.1.4